Paul Soto, Using Genetically Modified Organisms to Probe Neurobiological Bases of Behavior, SQAB

Chair: Jesse Dallery (University of Florida)

This tutorial will provide a general introduction to some technologies available for manipulating gene expression in mice. Technologies for manipulating gene expression can be used to investigate the neurobiological contributors to behavior. Results obtained from studies in dopamine receptor knockout mice on the role of dopamine receptors in food’s reinforcing efficacy will be used as an example of use of a global knockout approach. Results obtained from studies in Alzheimer’s transgenic APPswe/PS1dE9 mice on the role of beta amyloid in cognitive decline will be used as an example of a transgene approach. Additionally, the tutorial will discuss emerging technologies that allow precise control over the timing and location of modification of genetic expression. These emerging technologies allow behavioral researchers to investigate the role of neurobiological variables on behavior from a developmental perspective and to address questions regarding the role of particular brain regions in behavior. Genetically modified organisms provide a promising avenue for fruitful collaborations between behavior analysts and geneticists, neuroscientists, and scientists in other complementary areas.

behavioral genetics,behavior analysis,quantitative modeling,